General remarks - Belma Implants
Belma implants consist of a polymer reservoir surrounded by a hormone diffusion-controlling membrane. They are designed to release daily doses of a hormone to produce physiological or pharmacological plasma concentrations in mice and rats.
Two oestradiol implants have been developed. The first one makes it possible to achieve pre-ovulatory plasma concentrations and is used mainly in hormone-dependent cancer animal models to support tumour cell growth. The second one (E2 Light) makes it possible to deliver pro-oestrous doses and is designed for gynaecological models (e.g., endometriosis).
Table 1 : Plasma concentrations, normal values
|E2 (pg/ml)||2,4 – 145,4||2,4 – 145,4|
|P4 (ng/ml)||1,2 – 18,4||1,2 – 18,4|
|T (ng/ml)||0,66 – 5,4||1,7 – 14,4|
Table 2 : Plasma concentrations, values with Belma implants
|Belma E2 (pg/ml)||52 - 108||41,2 - 105,6|
|Belma E2L (pg/ml)||35,2 - 72,0|
|Belma P4 (ng/ml)||5,3 – 11,2||3,0 - 5,9|
|Belma T (ng/ml)||0,9 - 3,7||2,9 - 7,5|