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General remarks - Belma Implants

Belma implants consist of a polymer reservoir surrounded by a hormone diffusion-controlling membrane. They are designed to release daily doses of a hormone to produce physiological or pharmacological plasma concentrations in mice and rats.

Two oestradiol implants have been developed.  The first one makes it possible to achieve pre-ovulatory plasma concentrations and is used mainly in hormone-dependent cancer animal models to support tumour cell growth.  The second one (E2 Light) makes it possible to deliver pro-oestrous doses and is designed for gynaecological models (e.g., endometriosis).


Table 1 : Plasma concentrations, normal values

  Rat  Mouse
E2 (pg/ml) 2,4 – 145,4 2,4 – 145,4
P4 (ng/ml) 1,2 – 18,4 1,2 – 18,4
T (ng/ml) 0,66 – 5,4 1,7 – 14,4

Table 2 : Plasma concentrations, values with Belma implants

  Rat  Mouse
Belma E2 (pg/ml) 52 - 108 41,2 - 105,6
Belma E2L (pg/ml)   35,2 - 72,0
Belma P4 (ng/ml) 5,3 – 11,2 3,0 - 5,9
Belma T (ng/ml) 0,9 - 3,7  

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